日 時：１１月２０日（水）１２時～
場 所：小教室
演 題：Epigenetic alterations in Cancer：Basic principles and applications
演 者：Dun-Fa Peng, MD, PhD, Research Instructor, Surgical Oncology Research, Vanderbilt University Medical Center
内 容：
Abstract: Cancers have traditionally been considered as genetic disorders that are driven by stepwise accumulation of genetic alterations; such as gene mutation, deletion, insertion, fusion, copy number alteration, chromosomal instability etc. However, recent studies have added epigenetic alterations in the initiation and progression of tumor by deregulating gene expression. Epigenetics is referred as stably heritable phenotype resulting from changes in a chromosome without alterations in the DNA sequence; including DNA methylation, histone modifications, nucleosome remodeling as well as small non-coding regulatory RNAs . And the interplay between genetic and epigenetic alterations actually occurs through the carcinogenesis process. I will briefly introduce the basic concepts of genetics and epigenetics, the major genetic and epigenetic alterations in cancers and the common technologies available for studying these alterations. I will also give some experimental examples that I have done during the past years to discuss the possible application in research and clinical practice.
